Extracellular Vesicles  

Increasing evidence suggests that the  carriers of intercellular communication are  extracellular vesicles (EVs). They are a heterogeneous population of  membrane particles released into the extracellular space in vitro and in vivo,  or example exosomes and microvesicles. But how these structures are signaling from one cell to another remains  elusive. We study systematically the  secretion and signaling of EVs in the context of cell migration in tumor  cells and in vivo in Drosophila melanogaster. We focus on the cell biological mechanisms of EVs release.